Reading Group: Model sparsity and brain pattern interpretation of classification models in neuroimaging

SpeakerAndre Marquand
AffiliationDepartment of Neuroimaging, KCL
DateWednesday, 23 May 2012
Time16:00 - 17:00
LocationFoster Court 216
Event seriesMachine Learning for Neuroimaging Reading Group
Description

Interest is increasing in applying discriminative multivariate analysis techniques to the analysis of
functional neuroimaging data. Model interpretation is of great importance in the neuroimaging context,
and is conventionally based on a ‘brain map’ derived from the classification model. In this study we
focus on the relative influence of model regularization parameter choices on both the model generalization, the reliability of the spatial patterns extracted from the classification model, and the ability of
the resulting model to identify relevant brain networks defining the underlying neural encoding of the
experiment. For a support vector machine, logistic regression and Fisher’s discriminant analysis we
demonstrate that selection of model regularization parameters has a strong but consistent impact on
the generalizability and both the reproducibility and interpretable sparsity of the models for both ‘2
and ‘1 regularization. Importantly, we illustrate a trade-off between model spatial reproducibility and
prediction accuracy. We show that known parts of brain networks can be overlooked in pursuing
maximization of classification accuracy alone with either ‘2 and/or ‘1 regularization. This supports the
view that the quality of spatial patterns extracted from models cannot be assessed purely by focusing
on prediction accuracy. Our results instead suggest that model regularization parameters must be
carefully selected, so that the model and its visualization enhance our ability to interpret the brain.

iCalendar csml_id_93.ics